STUDY INFORMATION
Studies and Research Initiatives
At ZEG Berlin, we are continuously advancing our understanding of drug safety and real-world outcomes. Our ongoing pharmacoepidemiology and late-phase research covers the full lifecycle of medicines, with a particular focus on women’s health and hormonal therapies. Our active research portfolio reflects both the breadth of our expertise and our ongoing commitment to advancing evidence-based healthcare for women at every life stage. Explore our current research initiatives below.
Current studies: Real-World Evidence in Action
EURAS-LCS12
European Active Surveillance Study of LCS12
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2014–2027
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Women with a newly inserted Intrauterine Device
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N= ~ 97.000
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INAS-NEES
International Active Surveillance Study: Native Estrogen Estetrol (E4) Safety Study (INAS-NEES)
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2019–2029
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Women with a newly prescribed COC (E4/DRSP; EE/LNG)
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Venous thromboembolism
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N=101,000 planned
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We are still recruiting – please use our physician contact form if you are interested in participating.
https://catalogues.ema.europa.eu/node/3455/administrative-details
LIDEAR
Long-Term International Dual Source Endometriosis and Adenomyosis Registry (LIDEA Registry)
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2025-2030
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Dynamic Multi-Country Execution
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Women with diagnosed or presumed endometriosis or adenomyosis
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N= ~ 14,000 planned
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We are still recruiting – please use our physician contact form if you are interested in participating.
https://catalogues.ema.europa.eu/node/3842/administrative-details
GRACE
Fezolinetant Experience for the Treatment of Vasomotor Symptoms Associated with Menopause
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2024-2026
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Women who initiate fezolinetant for the treatment of VMS associated with menopause per routine clinical practice in Germany.
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N=~ 100
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Secondary Data
100+ Observational, Retrospective Studies
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Since 2017
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Patient Data from Representative Claims Databases
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Bone • Cardiovascular, Renal and Metabolism • Dermatology • Gastroenterology • General Health • Immunology • Infectious Diseases • Neurology • Oncology/Hematology • Ophthalmology • Rare Disease • Respiratory • Urology
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80+ Publications & Conference Contributions
Past studies: A selection of key studies
VIPOS
International Active Surveillance Study of Medication Used for the Treatment of Endometriosis: Visanne Post-approval Observation Study (VIPOS)
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2010–2019
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Women with a new hormonal therapy for endometriosis
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Anemia associated with endometriosis-related bleeding, first time occurrence or worsening of existing clinically relevant depression, discontinuation patterns due to treatment failure
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N=27,840
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PRO-E2
Prospective controlled cohort study on the safety of a monophasic oral contraceptive containing nomegestrol acetate (2.5mg) and 17ß-estradiol (1.5mg) (PRO-E2)
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2012–2021
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Women with a new prescription for combined oral contraceptives
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venous thromboembolism, arterial thromboembolism, depressive disorders, cholelithiasis, inflammatory bowel disease, effects on short- and long-term fertility and pregnancy outcomes.
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N=101,498
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EURAS-IUD
European Active Surveillance Study for Intrauterine Devices (EURAS-IUD)
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2006-2016
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Women with a newly inserted intrauterine device
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Perforations
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N=63,194
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EURAS-OC
European Active Surveillance Study of Oral Contraceptives (OC)
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2006–2009
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Women with a new prescription for oral contraceptives
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Drug utilization pattern
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N=58,674
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EURAS-OC
European Active Surveillance Study of Women Taking Hormone Replacement Therapy (HRT)
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2004-2014
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Women beginning oral continuous combined hormone therapy
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Venous and arterial thromboembolism
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N=30,597
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INAS-SCORE
International Active Surveillance study “Safety of Contraceptives: Role of Estrogens
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2009–2016
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Women with a new prescription for a combined oral contraceptive
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Venous and arterial thromboembolism
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N=50,203
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NORA
Nexplanon Observational Risk Assessment
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2011–2017
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Women with a newly inserted Nexplanon implant
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Unintended pregnacy
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N=7,364
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Study Physician Contact Form
Our studies rely on the participation of recruiting physicians, who identify suitable participants for our observational studies. As a recruiting physician you can make a big contribution to research with minimal effort.
Please enter your contact details if you are interested in participating in one of our studies as a recruiting physician: